Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides: Analytical Challenges Associated with Determination of Stereochemical Composition

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DOI:10.1021/acs.oprd.4c00380
作者：Tanja Poredo?, Marko Trampu?, Tja?a Gornik, Klemen Naver?nik, Ma?a Sinreih Tisnikar, Samo Pirc, Zdenko ?asar
文献类型：期刊论文
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Abstract：A surge in the approval of therapeutic oligonucleotides since 2016 has made this class of chemical modalities an essential toolbox for addressing unmet medical needs in the realm of rare or

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