Large library docking identifies positive allosteric modulators of the calcium-sensing receptor

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DOI:10.1126/science.ado1868
作者：Fangyu Liu,?Cheng-Guo Wu,?Chia-Ling Tu,?Isabella Glenn,?Justin Meyerowitz,?Anat Levit Kaplan,?Jiankun Lyu,?Zhiqiang Cheng,?Olga O. Tarkhanova,?Yurii S. Moroz,?John J. Irwin,?Wenhan Chang,?Brian K. Sho
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Positive allosteric modulator (PAM) drugs enhance the activation of the calcium-sensing receptor (CaSR) and suppress parathyroid hormone (PTH) secretion. Unfortunately, these hyperparathyroi

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