Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity

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DOI:10.1016/j.cell.2025.12.013
作者：Jason S. Rush, Joshua D. Wertheimer, Steven D. Goldberg, Donald Raymond, Mateusz Szuchnicki, Andrew J. Baltus, Jeff Branson, Christopher F. Stratton, Aaron N. Patrick, Ruth Steele, Suraj Adhikary, Ama
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Elsevier

Abstract：Human genetic association studies highlight key genes involved in disease pathology, yet targets identified by these analyses often fall outside the traditional definitions of druggability.

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