Exploiting Bridged Conformations for Precise Molecular Recognition in the Design of KRAS-Selective, Orally Available Macrocyclic Peptides

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DOI:10.1021/jacs.6c14212
作者：Mirai Kage,?Hatsuo Kawada,?Koji Takano,?Atsushi Matsuo,?Yoshihisa Murata,?Satoshi Hashimoto,?Minoru Tamiya,?Tomoya Kotake,?Shino Kuramoto,?Takashi Yamano,?Machiko Irie,?Kazuhiro Ohara,?Yuuji Sakurai,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Macrocyclic peptides are attracting attention as a promising therapeutic modality for addressing intracellular targets that are traditionally difficult to address with conventional small

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