Two Mechanisms One Molecule: Developing a ‘Truly’ Bifunctional Degrader Targeting Rpn13 and CRBN

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DOI:10.1021/jacs.6c02914
作者：Cody A. Loy,?Shawn E. Vinogradsky,?Darci J. Trader
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Targeted protein degradation (TPD) has emerged as a powerful strategy to eliminate disease-relevant proteins, yet current approaches remain largely constrained to hijacking ubiquitin liga

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