Glycolipids Substitute PEG lipids in Lipid Nanoparticles for mRNA Delivery

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DOI:10.1021/jacs.5c16448
作者：Jiahui Jin,&nbsp;, ,&nbsp;Zhifen Liang,&nbsp;, ,&nbsp;Ziqian Wang,&nbsp;, ,&nbsp;Xiaoyi Liu,&nbsp;, ,&nbsp;Xingwu Liu,&nbsp;, ,&nbsp;Fangjie An,&nbsp;, ,&am
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Lipid nanoparticles (LNPs) have become a pivotal platform for mRNA drug delivery, yet the immunogenicity of poly(ethylene glycol) (PEG) lipids compromises efficacy upon repeated administrati

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