Synthesis of a Crystalline Acylated Lysine Building Block for Retatrutide Manufacture

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DOI:10.1021/acs.oprd.6c00240
作者：Jingyao Wang,Jing Teng,Emily Guinn,Ryan W. Curtis,Rachel N. Richey,Sergey V. Tsukanov,Joel R. Calvin,Gordon Randall Lambertus,Mark A. Strege,Ankur Jalan,Michael E. Kopach
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Retatrutide contains a structurally complex lipidated side chain that presents significant challenges for efficient large-scale synthesis and isolation. We report the development of a novel

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