In vivo engineering of CAR natural killer cells for immunotherapy using ligand-directed lipid nanoparticles.

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DOI:10.1038/s41587-026-03310-1
作者：Yuang Chen, Julia Monkovic, Haseeb Mughal, Binlong Chen, Elina Thadhani, Patrick McMullen, Ava Self, Yuxuan Chen, Yizong Hu, Samuel Detmer, Min Chen,&
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Nature

Abstract：Targeted lipid nanoparticles (LNPs) offer a nonviral approach for in vivo cell engineering but efficient programming of natural killer (NK) cells remains underexplored. Here we develop NK ce

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