Synthesis of Fluorinated Tyr-GalNAc Antigens and Potent Antitumor Activity of Their Bacteriophage Qβ Conjugates

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DOI:10.1021/jacs.6c13140
作者：Jingyi Zhang,?Lu Huang,?Zihan Lyu,?Yunfan Liu,?Ruichuan Qi,?Binbin Hu,?Sicheng Long,?Ziyi Lu,?Xiaomeng Shi,?Bo Cheng,?Suwei Dong
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Tumor-associated carbohydrate antigens (TACAs) are promising targets for cancer immunotherapy but are limited by poor immunogenicity and antigen instability. Here, we report a vaccine le

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