Different freezing conditions differentially affect the stability of mRNA–lipid nanoparticles: A key role for freeze-concentrated phase residence

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DOI:10.1016/j.ijpharm.2026.127367
作者：Yi-Mei Sun, Siqingeerli Duonan, Dan-Ling Mei, Huan-Fang Xie, Jia-Yi Lv, Wei-Jie Fang
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1016/j.ijpharm.2026.127367

Elsevier

Abstract：Messenger RNA–lipid nanoparticles (mRNA-LNPs) are commonly stored frozen, but the effects of freezer conditions on post-thaw quality remain insufficiently understood. Two mRNA-LNP formulatio

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