Carboxylic Acid Bioisosteres of Creatine as Novel and Selective Substrate Competitive Inhibitors of the Creatine Transporter SLC6A8

已完结 10 由陈丽伊发布于 2026/10/30 10:28:24

DOI:10.1021/acs.jmedchem.5c02607
作者：Eduardo J. Martinez*,?, ,?Darren H. Wong,?, ,?Amish J. Patel,?, ,?Roy J. Vaz,?, ,?Robert W. Busby,?, ,?Robert Zahler,?, ,?Daniel Schefer,?, ,?Hui Zhao,?, ,?Xiaoming Xu,?, ,?Zizhao Liu,?, ,?Ruifang Men
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Creatine, a naturally occurring guanidine carboxylic acid, serves as a critical energy metabolite in tissues with high energy demands. Certain cancers upregulate creatine metabolism to suppl

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