Dynamic Reprogramming of PDGFRA-Expressing Stromal Cells Facilitates WNT-Driven Transformation by Promoting a Fetal-Like State in the Intestinal Epithelium.

已完结 20 由 w 发布于 2026/11/2 20:35:49

DOI:10.1158/0008-5472.can-25-0101
作者：Oscar Pellon-Cardenas,Prateeksha Rout,Sohaib Hassan,Emily Fokas,Isha Patel,Jay Patel,Xia Qiu,Ping He,Olivia Nussbaum,Alex Wu,Rohit Kumar,Masuda Akther,Alexandra Logerfo,Siwen Wu,Daniel Wagner,Dario Bo
文献类型：期刊论文
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American Association for Cancer Research (AACR)

Abstract：Stromal fibroblasts of the mesenchyme regulate critical signaling gradients along the crypt-villus axis in the intestine and provide a niche that supports intestinal stem cells. Here, we rep

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