Development of a Scalable Amidation-Dehydration Telescope Process for the Synthesis of Ibuzatrelvir

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DOI:10.1021/acs.oprd.6c00095
作者：Russell F. Algera,?Cindy Duong,?Doug Farrand,?Michael Herr,?Gary R Jolin,?Melissa Lee,?Lesly Mejia,?David W. Place,?Rachel Ruest,?Courtney Talicska,?R. Matthew Weekly,?Gerald A. Weisenburger,?Kaitlyn
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Ibuzatrelvir is a second-generation, orally administered inhibitor of the SARS-CoV-2 Mpro that has enhanced metabolic stability compared to nirmatrelvir. Although early manufacturing camp

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