An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses.

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DOI:10.1016/j.medj.2023.03.007
作者：Eva Gutierrez,?Mitchell Bigelow,?Colin LaCroix,?Jeremy Beech,?Patrick Kirby,?Lynn Markowitz,?Michael Shifrin,?Michael Naill,?Alexandra Braun,?Steve O'Neil,?Jean-Marie Cuillerot,?Ann Cheung,?Asya Grinb
文献类型：期刊论文
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Elsevier

Abstract：Background: Interleukin-12 (IL-12) has emerged as one of the most potent cytokines for tumor immunotherapy due to its ability to induce interferon γ (IFNγ) and polarize Th1 responses. Clinic

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