Lung neuroendocrine cancer induces immunosuppressive macrophages via serotonin to drive resistance to the T cell engager tarlatamab

已完结 10 由 honey 发布于 2026/11/2 11:13:24

DOI:10.1016/j.ccell.2026.09.016
作者：Kotaro Nomura,Tomoyo Fukami,Shinichiro Kato,Shunya Tanaka,Akito Fukuda,Yuki Koike,Masaki Kondo,Kazuhiro Kumagai,Takuma Irie,Genki Okumura,Tetsuro Taki,Shingo Sakashita,Masayuki Shirasawa,Tatsuya Yoshi
文献类型：期刊论文
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Elsevier

Abstract：Tarlatamab, a delta-like protein 3 (DLL3) × CD3-directed T cell engager (TCE), provides clinical efficacy against small cell lung cancers (SCLCs), although its efficacy remains limited, indi

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