Glioblastoma-secreted C1QL1 orchestrates tumor microtube expansion and neural synaptic pruning to drive malignant synapse formation and recurrence

已完结 40 由 HL 发布于 2026/8/14 11:40:37

DOI:10.1158/2159-8290.cd-25-1123
作者：Chaoqiong Ding, Jiayi Dong, Zhenzhong Pan, Shijie Liu, Qiuyue Song, Gaoxia Yang, Yuling Peng, Chuanxing Xie, Zongyao Huang, Wei Yao, Mengnan Wu, Yi Zhong, Wei Zhang, Yan Zhang, Songhua Wang, Weiwei Ma
文献类型：期刊论文
补充材料：仅需补充材料

American Association for Cancer Research (AACR)

Abstract：Glioblastoma (GBM) cells form neuron-to-glioma malignant synapses on neurite-like tumor microtubes (TMs), driving infiltrative growth and recurrence. The mechanisms underlying coordinated cr

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