De Novo-Designed Bifunctional Proteins for Targeted Protein Degradation

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DOI:10.1021/jacs.6c07593
作者：Bram Mylemans,Boguslawa Korona,Amanda M. Acevedo-Jake,Ailsa MacRae,Thomas A. Edwards,Danny T. Huang,Andrew J. Wilson,Laura S. Itzhaki,Derek N. Woolfson
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：In targeted protein degradation (TPD), specific subcellular proteins are removed by routing them to the ubiquitin-proteasome, autophagy, or lysosome machinery. For instance, proteolysis-targ

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