Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC)

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DOI:10.1021/acs.jmedchem.3c01174
作者：Adrian D. Hobson*,&nbsp;Jianwen Xu,&nbsp;Dennie S. Welch,&nbsp;Christopher C. Marvin,&nbsp;Michael J. McPherson,&nbsp;Bradley Gates,&nbsp;Xiaoli Liao,&nbsp;Markus Hollmann,
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American Chemical Society (ACS)

Abstract：Stable attachment of drug-linkers to the antibody is a critical requirement, and for maleimide conjugation to cysteine, it is achieved by ring hydrolysis of the succinimide ring. During ADC

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