Targeting cholesterol esterification sensitizes liver cancer to CD8⁺ T cell attack by impairing metabolic and redox resilience.

待确认 10 由浅浅忘发布于 2026/8/17 9:59:30

DOI:10.1016/j.immuni.2026.06.002
作者：Yange Gu,?Lulu Zhang,?Jianhua Li,?Ensi Ma,?Weiwei Hu,?Yun Liu,?Xiaocheng Du,?Feifei Zhang,?Tiange Yang,?Linyue Bian,?Wenfeng Li,?Yitian Jin,?Yinghua Wang,?Zihan Ning,?Chune Yu,?Dun Li,?Jing Zhao,?Chen
文献类型：期刊论文
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Elsevier

Abstract：Recurrence after tumor resection and liver transplantation remains a major clinical challenge in hepatocellular carcinoma (HCC). We examined tumor samples from HCC liver transplant patients

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Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience.

Targeting cholesterol esterification sensitizes liver cancer to CD8⁺ T cell attack by impairing metabolic and redox resilience.