De novo design of miniproteins targeting GPCRs.

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DOI:10.1038/s41586-026-10656-8
作者：Edin Muratspahi?,?David Feldman,?David E Kim,?Xiangli Qu,?Ana-Maria Bratovianu,?Paula Rivera-Sánchez,?Jan Hendrik Voss,?Emil P T Hertz,?Mads Jeppesen,?Federica Dimitri,?Kensuke Sakamoto,?Amrita Nalla
文献类型：期刊论文
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Nature

Abstract：G-protein-coupled receptors (GPCRs) have key roles in physiology and are central targets for drug discovery and development1,2, but the design of protein agonists and antagonists has been ch

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