Discovery of Highly Efficacious CRBN-Based KRAS Degraders Targeting Cancers with KRAS G12D and G12V Mutations

已完结 10 由顺势而为001 发布于 2026/8/26 8:41:02

DOI:10.1021/acs.jmedchem.6c01153
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.jmedchem.6c01153

American Chemical Society (ACS)

Abstract：KRAS G12D and G12V mutants account for >50% of human cancers carrying a mutated KRAS protein, and targeting KRAS proteins by induced protein degradation represents an attractive cancer thera

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