Structural optimization of Moracin M as novel selective phosphodiesterase 4 inhibitors for the treatment of idiopathic pulmonary fibrosis

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DOI:10.1016/j.bioorg.2024.107474
作者：Sen Wang , Guofeng Yang , Kai Zhang , Zhexin Chen , Meiying Qiu , Siyu Hou , Tiansheng Zheng , Zongmin Wu , Qinjiang Ma , Furong Zhang , Ge Gao ,&nbsp
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Elsevier

Abstract：Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and high mortality lung disease. Although the antifibrotic drugs pirfenidone and nintedanib could slow the rate of lung functio

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