Discovery of amentoflavone as a natural PDE4 inhibitor with anti-fibrotic effects

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DOI:10.1016/j.cclet.2024.109956
作者：Zhexin Chen , Yuqing Shi , Fang Zhong , Kai Zhang , Furong Zhang , Shenghong Xie , Zhongbin Cheng , Qian Zhou , Yi-You Huang , Hai-Bin Luo
文献类型：期刊论文
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Elsevier

Abstract：Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with high mortality rate but effective therapeutics are still lacking. Phosphodiesterase-4 (PDE4) inhibitors were reported t

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