Stereocontrolled First Generation Synthesis of RIPK1 Inhibitor GDC-8264

已完结 10 由 LZI 发布于 2026/5/30 16:08:02

DOI:10.1021/acs.oprd.5c00125
作者：Allen Y. Hong*,?Nicholas Wong,?Sean M. Kelly,?Lauren E. Sirois,?Sara Schwegler,?Xin Linghu,?Carmela Molinaro,?C. Gregory Sowell and Francis Gosselin,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：We report an efficient, stereocontrolled, and chromatography-free first-generation manufacturing process for GDC-8264 (1), a RIPK1 inhibitor. Key steps include a diastereoselective reductive

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