Prioritizing stability-enhancing mutations using the ESM protein language modelin conjunction with physics-based MM/GBSA predictions.

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DOI:10.1093/protein/gzag016
作者：Rhodes ER, Scarabelli G, Jou J, Byerly J, Sprenger KG, Oloo EO
文献类型：期刊论文
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Oxford University Press

Abstract：Directed evolution for protein engineering, as currently practiced in the biotechnology and pharmaceutical industries, is both tedious and expensive. Computationally driven protein design ha

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