Converting FGFR inhibitors into selective covalent molecular glue degraders via transposable gluing handles

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DOI:10.1016/j.ejmech.2026.119034
作者：Xiansheng Cao ,?Xiaohao Huang ,?Chongran Song ,?Shu Shi ,?Yongjuan Zhu ,?Lulu Zheng ,?Guang Liang ,?Lingfeng Chen
文献类型：期刊论文
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Elsevier

Abstract：Molecular glue degraders (MGDs) have emerged as a transformative therapeutic modality, offering the potential to deplete undruggable or pathogenic proteins. However, the rational design of M

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