Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer

已完结 10 由 w 发布于 2026/8/4 10:34:59

DOI:10.1038/s42255-026-01482-3
作者：Yun Yang, Yong Wu, Xin Guo, Wen-Juan Gan, Wen-Xin Wu, Wei-Yi Shi, Xiao-Shun He, Yi-Xuan Liu, Shan Wan, Zhi Jiang, Yue Liu, Xiu-Ming Li, Zu-D
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1038/s42255-026-01482-3

Nature

Abstract：Kirsten rat sarcoma (KRAS) mutations are key drivers of oncogenesis and therapy resistance in colorectal cancer (CRC), yet the underlying molecular mechanisms and effective targeted therapie

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