Pulmonary Delivery of Self-Amplifying RNA: Balancing Inflammation and Durable Transgene Expression.

已完结 10 由 yonghui zhang 发布于 2026/8/4 9:34:19

DOI:10.1021/acsnano.6c00709
作者：Qing Sun,Xiaole Cui,Haitao Li,Pieter Vervaeke,Stefan Lienenklaus,Oriane Gillon,Elisabeth De Sutter,Charlotte Helsmoortel,Bert Devriendt,Janne Snoeck,Niek N Sanders
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acsnano.6c00709

American Chemical Society (ACS)

Abstract：Self-amplifying mRNA (saRNA) is emerging as a leading platform for both vaccination and gene therapy. However, saRNA and the lipid nanoparticles (LNPs) used for their delivery activate t

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