Design of SC PEP with enhanced stability against pepsin digestion and increasedactivity by machine learning and structural parameters modeling.

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DOI:10.1016/j.ijbiomac.2023.125933
作者：Xiao B, Zhang C, Zhou J, Wang S, Meng H, Wu M, Zheng Y, Yu R
文献类型：期刊论文
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Elsevier

Abstract：Prolyl endopeptidases from Sphingomonas capsulata (SC PEP) has attracted much attention as promising oral therapy candidate for celiac sprue, however, its low stability in the gastric enviro

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