Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders

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DOI:10.1126/science.ady0832
作者：Anna M. Puszynska,&nbsp;Thao P. Nguyen,&nbsp;Andrew L. Cangelosi,&nbsp;Andrea Armani,&nbsp;Justin M. Roberts,&nbsp;Kristin A. Singh,&nbsp;James C. Cameron,&nbsp;Tenzin Tsey
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes

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