Peptidyl Asparaginyl Ligase-Mediated Orthogonal Ligation at Non-Asx Peptide Bonds for d-Peptide Cyclization and Antibody Dual Labeling

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DOI:10.1021/jacs.5c20426
作者：Hongxia Li, , , Yiyin Xia, , , Seetharamsing Balamkundu, , , Jiayong Liu, , , Fupeng Li, , , Xiaohong Zhang, , , Julien Lescar, , ,&nbs
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：There is an increasing need to develop enzymatic methods for protein modification. PALs (peptidyl asparaginyl ligases) catalyze transpeptidation at the Asx (Asn or Asp) peptide bond with hig

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