Senescent cancer-associated fibroblasts drive early-stage lymph node metastasis in pancreatic cancer through lactate-mediated metabolic-epigenetic rewiring

已完结 20 由斌斌发布于 2026/8/5 11:20:23

DOI:10.1158/2159-8290.cd-25-1627
作者：Tianxing Zhou, Jingrui Yan, Guohua Mao, Yu Zhang, Shangheng Shi, Tinghai Hu, Jingbo Xu, Yaqi Zhang, Zhi Ji, Qingxiao Fang, Zhaoyu Zhang, Zekun Li, Ziyun Liu, Yifei Wang, Hongwei Wang, Tiansuo Zhao, So
文献类型：期刊论文
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American Association for Cancer Research (AACR)

Abstract：Lymph node metastasis (LNM) in early-stage PDAC predicts systemic dissemination and poor survival, yet its underlying mechanisms remain elusive. Here, we demonstrated that senescent cancer-a

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