Major Progress in the Liquid-Phase Synthesis of N-Alkyl-Rich Cyclic Peptides: Kilogram-Scale GMP Production of the KRAS Inhibitor LUNA18

已完结 10 由小太阳发布于 2026/8/5 10:52:08

DOI:10.1021/acs.oprd.5c00260
文献类型：期刊论文
补充材料：只需要正文
文献链接：https://doi.org/10.1021/acs.oprd.5c00260

American Chemical Society (ACS)

Abstract：This article describes the development of a liquid-phase peptide synthesis (LPPS) process for LUNA18 (paluratide), an N-alkyl-rich cyclic undecapeptide with KRAS inhibitory activity. Departi

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