Manufacturing Process Development for Belzutifan, Part 4: Nitrogen Flow Criticality for Transfer Hydrogenation Control

已完结 10 由何尘发布于 2026/8/5 9:52:27

DOI:10.1021/acs.oprd.1c00231
作者：Nastaran SalehiMarzijarani*,?Adam J. Fine,?Stephen M. Dalby,?Rekha Gangam,?Samiksha Poudyal,?Taylor Behre,?Anil R. Ekkati,?Brittany M. Armstrong,?C. Scott Shultz,?Zachary E. X. Dance,?Kevin Stone*
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：A scalable and efficient synthesis of hydroxyindanone 3, a key intermediate for belzutifan (MK-6482), is described. Mechanistic studies revealed the sensitivity of the reduction reaction tow

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