Structure-Guided Engineering of Carbonyl Reductase LbCR to Simultaneously Enhance Catalytic Activity and Thermostability toward Bulky Ketones

已完结 10 由 lalalala 发布于 2026/8/7 18:42:35

DOI:10.1021/acs.jafc.5c01462
作者：Li?li Yao, Bin Xue, Yuan-Fan Ye, Zhi-Xiu Wang, Yang-Yang Li, Bei-Feng-Chu Zheng, Shu-Yun Ju, Ya-Jun Wang
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：(S)-2-Chloro-1-(2,4-dichlorophenyl)ethanol ((S)-TCPE) is an important building block for the synthesis of antifungal drug luliconazole. Herein, a carbonyl reductase (CR) from Levilactobacill

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