Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling

待确认 10 由 xiaohong 发布于 2026/8/7 17:40:15

DOI:10.1126/science.adt0548
作者：Yuanheng Yang, Cong Hao, Tingying Jiao, Zidan Yang, Hui Li, Yuqing Zhang, Weiya Zhang, Michael Doherty, Chuying Sun, Tuo Yang, Jiatian Li, Jing W
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：Whether a gut-joint axis exists to regulate osteoarthritis is unknown. In two independent cohorts, we identified altered microbial bile acid metabolism with reduced glycoursodeoxycholic acid

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