Discovery of BMS-986458, a Potent and Selective B-Cell Lymphoma 6 Protein Ligand-Directed Degrader, for the Treatment of B-Cell Non-Hodgkin Lymphoma

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DOI:10.1021/acs.jmedchem.5c03123
文献类型：期刊论文
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文献链接：https://doi.org/10.1021/acs.jmedchem.5c03123

American Chemical Society (ACS)

Abstract：B-cell lymphoma 6 protein (BCL6) is an oncogenic driver dysregulated and overexpressed in subtypes of high-risk non-Hodgkin lymphoma (NHL). Development of agents that induce the targeted deg

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