Discovery and Optimization of a WRN Helicase Inhibitor Series through Structure-Guided Drug Design from a Covalent Fragment Binding Insight

已完结 10 由 leek 发布于 2026/8/11 17:22:04

DOI:10.1021/acs.jmedchem.6c00443
作者：Momar Toure,Xin Cindy Yan,Yonghong Bai,Brian A. Sosa-Alvarado,Cen Gao,Theresa Baker,Erin Brophy,John R. Butler,Yuchen Yuan,Michael H. Reutershan,Anthony Tubbs,Laurie Schenkel,Giulia Bottoni,Erica Evan
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：WRN helicase activity inhibition has emerged as a promising therapeutic approach for targeting cancer cells with specific DNA repair deficiencies, especially those with microsatellite instab

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