Quality by design of solid-phase peptide/protein coupling reaction via mechanistic reaction kinetics modeling approach

已完结 10 由 ASshen 发布于 2026/8/11 15:02:14

DOI:10.1002/aic.18453
作者：Jingyao Wang,?Paridhi Agrawal,?Mark R. Berglund,?Jennifer McClary Groh,?Michael E. Kopach,?Kevin D. Seibert,?Shekhar K. Viswanath
文献类型：期刊论文
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Wiley

Abstract：The peptide coupling reaction is one of the most critical steps in the solid phase synthesis of therapeutic peptides/proteins. Improper reaction conditions can result in several common impur

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