Optimization of the Solid-Phase Oligonucleotide Detritylation Reaction Using In-Line IR Spectroscopy

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DOI:10.1021/acs.oprd.6c00103
作者：Yifan Yang,?, ,?Zhangbin Guan,?, ,?Ran Wang,?, ,?Wenqing Wang,?, ,?Meihui Zhang*,?, ,?Xiaoye Su*,?, and ,?Yu Shao*,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The solid-phase synthesis is a critical step in the oligonucleotide manufacturing process, and the detritylation reaction, as an essential procedure in oligonucleotide synthesis, directly af

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