Sequence Engineering of Guide DNA for Precise RNA Targeting by Cas12a

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DOI:10.1021/acsnano.6c02663
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Cas12a is highly accommodative toward noncanonical activation pathways to the extent of flipping its identity to be a DNA-guided RNA-targeting effector. A sequence engineering approach wa

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