Rationalizing nose-to-brain drug delivery: Machine learning-guided optimization and mechanistic elucidation of olfactory deposition for nasal sprays

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DOI:10.1016/j.jconrel.2026.114667
作者：Zizhao Zhai , Wenhao Wang , Guanlin Wang , Chunfu Wei , Shuhua Wei , Jinxia Li , Lingling Zheng , Xiao Yue , Chuangxin Chen , Junhuang Jiang , Bing Zh
文献类型：期刊论文
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Elsevier

Abstract：Nose-to-brain drug delivery via nasal sprays is severely limited by low olfactory deposition. In this study, we integrate machine learning with high-throughput experimentation to systematica

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