Discovery of Potent, Selective and Efficacious Aminopyrazole Inhibitors of PLK4

已完结 10 由懒洋洋发布于 2026/8/12 11:43:45

DOI:10.1021/acs.jmedchem.5c02200
作者：Joon Won Jeong*, , , Trevor Chang, , , Jeremy M. Murray, , , Ryan L. Gonciarz, , , Justin M. Salvant, , , Andre H. St. Amant, , , Sanjay Bha
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Polo-like kinase 4 (PLK4) is a therapeutic target of high interest due to its essential role in mitotic regulation and centriole duplication. Recently, centriole depletion driven by PLK4 inh

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