Design, synthesis, and biological evaluation of 6-aryl-1-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[4,3-c]pyridine derivatives targeting the colchicine-binding site as new tubulin inhibitors

已取消 10 由懒洋洋发布于 2026/8/12 11:40:32

DOI:10.1016/j.ejmech.2026.118827
作者：Zhu Guo , Chang Liu , Yujing Zhang , Qianqian Xu , Liya Cui , Wujun Chen , Chao Wang
文献类型：期刊论文
补充材料：只需要正文

Elsevier

Abstract：Microtubules, dynamic cytoskeletal polymers whose structural subunit is tubulin, represent a well-established target for anticancer drug discovery. The development of small-molecule inhibito

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