Succinate drives macrophage inflammation by promoting GPR91 mitochondrial signaling in rheumatoid arthritis

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DOI:10.1126/scitranslmed.aea8468
作者：Wankang Zhang, Luping Wang, Yingjie Zhao, Yao Mu, Lei Qiu, Xinyu Feng, Yueye Wang, Jiemin Zhao, Yan Chang, Wei Wei, Xuezhi Yang
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：High succinate concentrations are implicated in rheumatoid arthritis (RA) and other inflammatory diseases through G protein–coupled receptor 91 (GPR91)–mediated signaling. Despite the therap

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