Lactylation-related prognostic signature characterized in pancreatic ductal adenocarcinoma through public scRNA-seq dataset and machine learning algorithms: the TOP2A-H3K18la-NQO1 axis orchestrates malignant progression

已完结 10 由祁茵发布于 2026/9/13 10:49:05

DOI:10.1038/s41416-026-03477-z
作者：Haodong Tang, Tonglei Xu, Li Liu, Yusheng Du, Dan Liu, Siyuan Tan, Peiyuan Shen, Aozhong Hu, Xiangxu Shi, Hongqin Ma, Ji Wang, Wenxing Zhao
文献类型：期刊论文
补充材料：只需要正文

Nature

Abstract：Lactate promotes histone lactylation, which affects protein transcription and translation, thereby influencing tumour cell progression. However, the role of lactylation in pancreatic ductal

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