De Novo Discovery of a Macrocyclic Peptide Antagonist of Interleukin-11 with Antirenal Fibrotic Efficacy

已完结 10 由 1 发布于 2026/5/8 16:05:32

DOI:10.1021/acs.jmedchem.5c01432
作者：ChunMei An, , , Wenfeng Cai, , , Peiying Li, , , Jian Li, , , Na Zhao, , , Xu Yang, , , Keqiang Li, , , Ningning Pang, , ,&nb
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Emerging evidence has highlighted the pathological involvement of interleukin-11 (IL-11) in fibrotic disorders. In this study, we identified a novel peptide antagonist 4L2 through the random

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