General Synthesis of Conformationally Constrained Noncanonical Amino Acids with C(sp3)-Rich Benzene Bioisosteres

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DOI:10.1021/acs.joc.4c00225
作者：Xiaoshen Ma*,?Adam M. Beard,?Samantha A. Burgess,?Miroslawa Darlak,?Justin A. Newman,?Lisa M. Nogle,?Mark J. Pietrafitta,?David A. Smith,?Xiao Wang and Lei Yue,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Recent years have seen novel modalities emerge for the treatment of human diseases resulting in an increase in beyond rule of 5 (bRo5) chemical matter. As a result, synthetic innovations aim

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