Glutarimide-derived ionizable lipid enables mRNA lipid nanoparticle vaccines with enhanced safety and immunogenicity

已完结 10 由 Jehiah 发布于 2026/9/15 9:51:42

DOI:10.1016/j.jconrel.2025.114482
作者：Sha Li , Lu Zheng , Zixuan Zhang , Jianhua Zhang , Xiaoxiao Liu , Jinliang Xu , Rong Yang , Yaqi Yang , Yue Zhao , Jingyi Zhong , Runping Su , Li
文献类型：期刊论文
补充材料：只需要正文

Elsevier

Abstract：While lipid nanoparticle (LNP)-mRNA vaccines have shown remarkable clinical success, their broader application remains limited by relatively low stability, dose-dependent toxicity, and subop

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