Bridged-Backbone Strategy Enables Asymmetric Synthesis of Highly Functionalized Oxabicyclo[3.3.1]nonanes with Anti-Osimertinib-Resistant NSCLC Activity

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DOI:10.1021/jacs.5c11520
作者：Chao Yang, , , Xueping Lei*, , , Xian-Bo Chen, , , Ni-Ping Li, , , Boyin Li, , , Yu-Xin He, , , Shi-Lin Lin, , , Ming Chen, ,
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：The synthesis of highly functionalized oxa[3.3.1]-bridged bicycles remains challenging because of ring strain and the presence of multiple stereocenters. Herein, we report a Brønsted acid-ca

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